FIGURE 1.

Ca_V1.2 molecular complex in the regulation of VSM contraction and transcription. Ca²⁺ influx through Ca_V1.2 channels is essential for the pressure-induced contraction of the VSM (Moosmang et al., 2003). Activation of G_s/PKA signaling by high glucose or G_q/PKC by angiotensin II potentiate Ca_V1.2 activity (Navedo et al., 2008; Navedo et al., 2010b; Prada et al., 2019). The scaffolding protein AKAP5 facilitates PKA/PKC phosphorylation of Ca_V1.2 channels at S1928 (Nystoriak et al., 2017a). The phosphatase PP2B opposes phosphorylation dampening Ca_V1.2 potentiation. Graphics created with BioRender.com.