TABLE 3.

Functional significance of select Mafg ^−/−:Mafk ^−/− differentially expressed candidates.

Gene	Effect in Mafg −/−:Mafk −/− lens	Description	Functional significance	References
Camsap1	Up	Calmodulin regulated spectrin associated protein 1	Involved in cytoskeletal control	[Jiang et al., 2014; King et al., 2014; Xiang et al. (2016)]
Cdk1	Down	Cyclin dependent kinase 1	Involved in cell cycle progression	Santamaría et al. (2007)
Cdkn1c	Up	Cyclin dependent kinase inhibitor 1C	Involved in cell cycle inhibition	Zhang et al. (1998)
Col3a1	Up	Collagen type III alpha 1 chain	Involved in extracellular matrix control	Kuivaniemi and Tromp, (2019)
Epha5	Down	Eph receptor A5 (Tyrosine kinase)	Involved in signaling with Efna5 (ephrin-A5 ligand) to control cell-cell contract mediated events	Akaneya et al. (2010)
Hmox1	Up	Heme oxygenase	Involved in oxidative stress response	Zheng et al. (2010)
Lars2	Down	Mitochondrial leucyl-tRNA synthetase	Involved in mitochondrial protein synthesis; homolog associated with autophagy	Pierce et al. (2013)
Map3k12	Down	Mitogen-activated protein kinase kinase 12 (Leucine-zipper domain and serine/threonine protein kinase)	Involved in cell cycle control and differentiation	[Robitaille et al., 2005, Robitaille et al., 2010; Daviau et al. (2011)]
Pxdn	Up	Peroxidasin	Involved in extracellular matrix formation	[Khan et al., 2011; Yan et al. (2014)]
Sipa1l1	Down	Signal induced proliferation associated 1 like 1	Potentially involved in actin cytoskeleton organization	[Pak et al., 2001; Matsuura et al. (2021)]
Trex1	Down	Three prime repair exonuclease 1	Potentially involved in DNA repair	Yang et al. (2007)