TABLE 1.

Function of angiogenesis-related cytokines in promoting angiogenesis.

Cytokines	Function
MMP	Degradation of collagen around microvessels in the early stage of angiogenesis
VEGF	Proliferation and migration of endothelial cells, change of vascular permeability, and extracellular matrix degeneration
FGF	Endothelial cell migration, smooth muscle cell proliferation, and the gradual maturation of newly formed vascular lumen
eNOS	Regulation of NO synthesis. The angiogenic effects of FGF-2 and VEGF are closely related to the NO signaling pathway