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. 2022 Aug 26;13:981577. doi: 10.3389/fphys.2022.981577

TABLE 2.

The mechanisms of myokines in promoting angiogenesis.

Myokines Glucose and lipid metabolism Angiogenesis-related cytokines Other myokines
Hyperlipidemia Hyperglycemia Insulin Resistance VEGF MMP eNOS/NO
IL-6
CXCL1 IL-6↑
CXCL10
Irisin CXCL1↑
FSTL1 IL-6↑
IGF-1

↑, up-regulated; ↓, down-regulated; –, not clarified or controversial.