TABLE 3.
The effects of Gynostemma Pentaphyllum on dyslipidemia from 22 randomized controlled trials.
| Outcome | Control | No. of studies | No. of participants | I2, model (REM/FEM) | Effect size MD mmol/L [95% CI] | Quality of evidence (GRADE) |
|---|---|---|---|---|---|---|
| Gynostemma Pentaphyllum versus control | ||||||
| TC level | Lipid-lowering agents | 7 | 491 | 90%, REM | 0.52 [−0.01, 1.04] | Very low certainty |
| Red yeast rice | 5 | 859 | 96%, REM | 0.64 [0.15, 1.13] | Low certainty | |
| Hibiscus sabdariffa | 1 | 48 | 0%, FEM | −0.42 [−0.97, 0.13] | Low certainty | |
| TG level | Lipid-lowering agents | 7 | 491 | 91%, REM | 0.13 [−0.21,0.47] | Very low certainty |
| Red yeast rice | 5 | 859 | 96%, REM | 0.43 [0.15, 0.17] | Low certainty | |
| Hibiscus sabdariffa | 1 | 48 | 0%, FEM | −0.24 [−0.62, 0.15] | Low certainty | |
| LDL-C level | Lipid-lowering agents | 6 | 461 | 84%, REM | 0.57 [0.20, 0.93] | Low certainty |
| Red yeast rice | 3 | 621 | 99%, REM | 0.37 [−0.46, 1.20] | Very low certainty | |
| Hibiscus sabdariffa | 1 | 48 | 0%, FEM | −0.32 [−0.77, 0.13] | Low certainty | |
| HDL-C level | Lipid-lowering agents | 7 | 491 | 99%, REM | −0.34 [−0.93, 0.25] | Very low certainty |
| Red yeast rice | 4 | 781 | 96%, REM | −0.25 [−0.47, −0.04] | Low certainty | |
| Hibiscus sabdariffa | 1 | 48 | 50%, FEM | 0.10 [−0.08, 0.28] | Low certainty | |
| Gynostemma pentaphyllum plus lipid-lowering agents versus lipid-lowering agents | ||||||
| TC level | Lipid-lowering agents | 4 | 364 | 98%, REM | −1.05 [−2.28, 0.19] | Very low certainty |
| TG level | Lipid-lowering agents | 4 | 364 | 92%, REM | −0.65 [−1.03, −0.28] | Low certainty |
| LDL-C level | Lipid-lowering agents | 3 | 334 | 85%, REM | −0.57 [−1.07, −0.08] | Moderate certainty |
| HDL-C level | Lipid-lowering agents | 4 | 364 | 71%, REM | 0.15 [0.11, 0.20] | Low certainty |
Note: GP: Gynostemma pentaphyllum; No: number; REM: random-effects model; FEM: fixed-effects model; MD: mean difference; CI: confidence interval; TC:total cholesterol; TG:triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.