TABLE 2.
Parameter | Figure | 5 Res | 10 Res | 15 Res | W/D 20 days |
Catalepsy duration | 2 | ns | ↑ | ↑ | ns |
Tyrosine Hydroxylase/SNpc (IH) | 3 | ns | ↑ | ↑ | ns |
GFAP/DS (IH) | 4 | ns | ns | ↑ | ns |
GFAP/SNpc (IH) | 4 | ns | ↑ | ↑ | ↑ |
IBA 1/DS (IH) | 5 | ↑ | ↑ | ni | ↑ |
IBA 1/SNpc (IH) | 5 | ns | ↑ | ni | ns |
CD11b/DS (IH) | 6 | ↑ | ni | ns | ↑ |
CD11b/SNpc (IH) | 6 | ↑ | ni | ↑ | ↑ |
CD11b + iNOS/DS (IF) | 7 | ns | ni | ↑ | ns |
CD11b + iNOS/SNpc (IF) | 7 | ns | ni | ↑ | ns |
CD11b + Arg I/DS (IF) | 8 | ns | ni | ns | ↑ |
CD11b + Arg I/SNpc (IF) | 8 | ns | ni | ns | ↑ |
TNF-α/DS (RTPCR) | 9 | ns | ↑ | ni | ns |
IL-1β/DS (RTPCR) | 9 | ns | ns | ni | ns |
IL-10/DS (RTPCR) | 9 | ns | ns | ni | ↑ |
α-synuclein/DS (IH) | Suppl. | ↑ | ↑ | ni | ↑ |
α-synuclein/SNpc (IH) | Suppl. | ↑ | ↑ | ni | ns |
Outcomes after 5, 10, or 15 injections of reserpine (Res) or after 20 days of treatment withdrawal (W/D 20 days) compared to vehicle-treated groups.↑, increase; ↓, decrease; ns, no significant effect; ni, not included in the analysis; DS, dorsal striatum; SNpc, substantia nigra pars compacta; IH, immunohistochemistry assay; IF, immunofluorescence assay.