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. 2022 Aug 26;14:910988. doi: 10.3389/fnagi.2022.910988

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Copyright © 2022 Brandi, Torres-Garcia, Svanbergsson, Haikal, Liu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regional specific microglia activation to different doses of LPS in C57BL6 mice. (A) Percentage of marked area by Iba1 in vehicles (white columns), LPS treated mice with 0.005 mg/kg (clear gray columns), 0.05 mg/kg (medium gray columns), 0,5 mg/kg (dark gray columns), 5 mg/kg (black columns). Two-way ANOVA. F_{Brain Regions} (15, 160) = 57.94, p < 0.0001. F_Treatment (4, 160) = 188,3, p < 0.0001. F_Interaction (60, 160) = 1.599, p < 0.0110, and n = 3 mice per region. Significance: respect relative vehicles. (B) Iba1 positive cell density mm². Same column color as graph (A). Two-way ANOVA. F_{Brain Regions} (15, 160) = 112.7, p < 0.0001. F_Treatment (4, 160) = 222.1, p < 0.0001. F_Interaction (60, 160) = 2.039, p < 0.0002, and n = 3 mice per region. Significance: (*) Significance: respect relative vehicles. (C) Relative changes in percentage of area marked by Iba1. Same column color as graph (A). Two-way. F_{Brain Regions} (15, 160) = 4.169, p < 0.0001. F_Treatment (4, 160) = 202.4, p < 0.0001. F_Interaction (60, 160) = 1.259, p < 0.1304, and n = 3 mice per region. Significance: (*) respect relative vehicles. (D) Relative changes in Iba1 positive cell density. Same column color as graph (A). Two-way ANOVA. F_{Brain Regions} (15, 160) = 5.660, p < 0.0001. F_Treatment (4, 160) = 247.6, p < 0.0001. F_Interaction (60, 160) = 1.848, p < 0.0013, and n = 3 mice per region. Significance: (*) respect relative vehicles. (E) Representative images of Iba 1 staining in Veh, 0.05 and 5 mg/kg LPS doses in NAc, striatum, PSM cortex and cerebellum. Scale bars = 50 um in (E) and 10 um insets.