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. 2022 Aug;13(4):1690–1700. doi: 10.21037/jgo-22-651

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2022 Journal of Gastrointestinal Oncology. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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PPI and functional analyses. (A) The PPI network. The circular nodes represent the upregulated genes, and the square nodes represent the downregulated genes. The blue nodes show the genes in cluster 1, the green nodes show the genes in cluster 2, and the pink nodes show the genes in cluster 3. The size of each node represents the degree value. (B) The KEGG pathway enrichment analysis of the hub genes in the PPI network. The hub genes were those with a degree ≥5. PPI, protein-protein interaction, KEGG, Kyoto Encyclopedia of Genes and Genomes.