Table 1. Hub genes with a degree ≥5 in the PPI network.
| Nodes | Regulation | Cluster | Degree |
|---|---|---|---|
| COL3A1 | Up | Cluster 3 | 18 |
| COL1A2 | Up | Cluster 3 | 17 |
| COL1A1 | Up | Cluster 3 | 17 |
| COL18A1 | Up | Cluster 3 | 17 |
| COL4A1 | Up | Cluster 3 | 15 |
| COL5A1 | Up | Cluster 3 | 15 |
| COL5A2 | Up | Cluster 3 | 14 |
| THBS1 | Up | Cluster 3 | 14 |
| FN1 | Up | Cluster 3 | 14 |
| ALDH1A1 | Down | Cluster 2 | 13 |
| COL4A2 | Up | Cluster 3 | 13 |
| COL6A3 | Up | Cluster 3 | 13 |
| COL11A1 | Up | Cluster 3 | 13 |
| COL10A1 | Up | Cluster 3 | 12 |
| PTGS2 | Up | Cluster 3 | 12 |
| AKR1C3 | Down | Cluster 1 | 11 |
| COL12A1 | Up | Cluster 3 | 11 |
| THBS2 | Up | Cluster 3 | 11 |
| IL8 | Up | Cluster 3 | 10 |
| ALDH3A1 | Down | Cluster 1 | 9 |
| UGT2B15 | Down | Cluster 1 | 9 |
| CYP2C9 | Down | Cluster 1 | 9 |
| COMP | Up | Cluster 3 | 9 |
| AKR1C1 | Down | Cluster 1 | 7 |
| CYP3A5 | Down | Cluster 1 | 7 |
| CYP2C19 | Down | Cluster 1 | 7 |
| VEGFC | Up | Cluster 3 | 7 |
| SPP1 | Up | Cluster 3 | 7 |
| ADH1A | Down | Cluster 1 | 6 |
| AKR1C2 | Down | Cluster 1 | 6 |
| ADH7 | Down | Cluster 2 | 6 |
| PDGFRB | Up | Cluster 3 | 6 |
| ANGPT2 | Up | Cluster 3 | 6 |
| DHRS9 | Down | Cluster 1 | 5 |
| CBR1 | Down | Cluster 1 | 5 |
| ATP4A | Down | Cluster 2 | 5 |
PPI, protein-protein interaction.