Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Modes of action of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs). (A) Gapmer‐type ASO binds to the target RNA and forms the RNA/DNA heteroduplex in the central gap region, and RNase H cleaves the RNA strand of the heteroduplex. (B) Effect of siRNA. siRNA is composed of two complementary strands, the passenger strand and the guide strand. The latter binds to AGO2, inducing the degradation of complementary mRNA
