TABLE 3.
Sequence analysis of inhA alleles from temperature-resistant (Tr) revertants
| Strain | Phenotype | DNA change(s) | Amino acid change | No. with phenotype/no. of mutants analyzed |
|---|---|---|---|---|
| Revertants of mc22359 [inhA(Ts)] | ||||
| mc22363, mc22364 | Tr INH-Sa | 712TTA, 712TTG | F238L | 4/9 |
| mc22365 | Tr INH-S | 712TGC | F238C | 1/9 |
| mc22366 | Tr INH-R | 304TGT | G102C | 4/9 |
| Revertants of mc22360 [inhA(Ts)] | ||||
| mc22367 | Tr INH-S | 712GTC | F238V | 1/10 |
| mc22368, mc22369, mc22370 | Tr INH-S | 712TTA, 712TTG, 712CTC | F238L | 4/10 |
| mc22371 | Tr INH-S | 712TGC | F238C | 2/10 |
| mc22372 | Tr INH-R | 712ATC | F238I | 1/10 |
| mc22373 | Tr INH-R | 304TGT | G102C | 2/10 |
a
INH-S, INH susceptible.