Table 5.
Cox regression analysis for disease recurrence and death.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Disease Free Survival | ||||||
| Age (>70) (yrs) | 1.01 | 0.98-1.04 | 0.455 | |||
| Tumor size >4 cm | 1.04 | 0.93-1.15 | 0.515 | |||
| Tumor stage (T3-4) | 5.53 | 3.19-9.56 | <0.001 | 5.18 | 2.98-8.99 | <0.001 |
| N stage (N1-2) | 1.40 | 0.73-2.68 | 0.310 | |||
| Concomittant CIS | 0.87 | 0.51-1.48 | 0.603 | |||
| eGFR<60 (mL/min/1.73 m2) | 2.67 | 1.57-4.55 | <0.001 | 2.29 | 1.33-3.93 | 0.003 |
| Urine pH ≤ 5.5 | 1.72 | 1.02-2.90 | 0.043 | 1.69 | 1.00-2.86 | 0.050 |
| Overall Survival | ||||||
| Age (>70) (yrs) | 1.59 | 0.71-3.56 | 0.264 | |||
| Tumor size >4 cm | 2.18 | 0.96-5.00 | 0.064 | |||
| Tumor stage (T3-4) | 7.60 | 3.05-18.9 | <0.001 | 7.15 | 2.65-19.3 | <0.001 |
| N stage (N1-2) | 3.16 | 1.39-7.15 | 0.006 | 1.08 | 0.45-2.62 | 0.862 |
| Concomittant CIS | 1.03 | 0.47-2.27 | 0.943 | |||
| eGFR<60 (mL/min/1.73 m2) | 1.04 | 0.39-2.78 | 0.932 | |||
| Urine pH ≤ 5.5 | 2.47 | 1.07-5.69 | 0.034 | 2.66 | 1.11-6.40 | 0.029 |
eGFR, estimated glomerular filtration.