Figure 3:

VDAC2 deletion in cardiomyocytes causes defects in ECC. A) legend for Ca²⁺ handling proteins in C. B) Cytosolic and Mitochondria Ca2+ responses in WT and VDAC2 KO cells. Deletion of VDAC2 leads to a reduction in Ca²⁺ release and reduced Ca²⁺ transfer into mitochondria. VDAC1 may have more a role in regulating redox signaling and apoptosis, whereas VDAC2 has a dominant role in Ca²⁺ signaling.