Table 1:
Clinical Trials registered in ClinicTrials.gov targeting mitochondria function in patient with heart failure.
| Intervention | Target | Citations |
|---|---|---|
| Mito Q | Mitochondrial Antioxidant | [95] |
| Epicatechin | ETC | [96] |
| Ferric Carboxymaltose | ETC- Cytochome-Fe binding | [97] |
| 14N Sodium Nitrate | NO-CGAMP signaling | [98] |
| Nicotinamide ribose | SIRT/NAD+ signaling | [99, 100] |
| 3-hydroxybutyrate | Ketone oxidation | [101, 102] |
| Clonidine | a-adrenergic blocker | [103] |
| Empagliflozin | Sodium Glucose Transporter 2 inhibitor | [104] |
| Beet Root Juice | Mitochondrial efficiency; NO availability | [105] |
| KNO3 + L-carnitine | Enhances oxidative phos | [106] |
| Dapagliflozin | Sodium Glucose Transporter 2 inhibitor | [107, 108] |
| Sodium Valproate | FAO | [109, 110] |