Fig. 1.

Growth of xenografts depends on the host mouse strain. (A) MDA-MB-231 cells were xenografted subcutaneously into the five strains, and the tumor sizes were measured for 4 weeks. The data shown are from pooled male and female mice from three experiments. (B) MDA-MB-231 cells were xenografted in the mammary fat pad and measured for 4 weeks. (C) Comparative size at Day 21 between the subcutaneous and mammary fat pad growth of MDA-MB-231 cells in each strain. MFP, mammary fat pad; NS, not significant; SQ, subcutaneous. (D) Representative images and graph showing bioluminescence of MEC1 leukemia cell line and engraftment showing growth in the three strains studied (data pooled from two experiments). (E) Representative images and graph showing bioluminescence of GL261 glioma cell line and engraftment showing growth in all three strains. For all cell lines and xenografts in this figure, each dot represents one mouse, the bar shows the median, and the P-value is calculated by unpaired, two tailed Student’s t-test.