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. 2022 Aug 29;15(9):dmm049457. doi: 10.1242/dmm.049457

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Tumor-infiltrating myeloid cells positively correlate with tumor size. (A) Representative flow cytometer gating used to detect CD45⁺ cells (white blood cells) in the tumor. (B) Proportion of CD45⁺ cells in the tumor in Rag1^−/− mice of different strains. Box and whisker plot (boxes show 5-95% confidence interval with the median, whiskers indicate 95% confidence interval; N=7 biological replicates from each strain) showing the percentage of CD45⁺ cells in the tumor. Only pairwise statistically significant values are shown. (C) Pie charts showing cell type distribution with the CD45⁺ population. Macro, macrophages; Granulo, granulocytes; Neutro, neutrophils; NK, natural killer cells; Dendritic, dendritic cells; Mono, monocytes. (D) Distribution of different myeloid populations within the CD45⁺ pool from each strain. Boxes show 5-95% confidence interval with the median, whiskers indicate 95% confidence interval (N=7 biological replicates from each strain). Statistical analysis of each myeloid population for each strain is shown in Fig. S7.