Table 2. The likely pathogenic variants identified in mediastinal lymph nodes metastases.

Genes	Variants	Abundance	Clinical significance
TP53	Exon 5 c.451C>T (p.P151S)	61.32%	Missense mutation (putative driver)
CSMD3	Exon 69 c.10574T>C (p.V3525A)	3.95%	Missense mutation (unknown significance)
PARP4	Exon 29 c.3509C>T (p.T1170I)	8.04%	Missense mutation (unknown significance)
PTEN	Exon 6 c.611C>T (p.P204L)	50.83%	Missense mutation (putative driver)