Table 2. Cox regression and LASSO combine Cox regression of clinical characteristics for prognosis of SCC for OS.

Variable	COX					LASSO
	adj.p	HR	95% CI, lower	95% CI, upper		adj.p	HR	95% CI, lower	95% CI, upper
First time characteristics
Age (years)	<0.001	2.293	2.091	2.514		<0.001	2.327	2.129	2.544
Sex	<0.001	0.794	0.727	0.868		<0.001	0.816	0.749	0.889
Site	0.023	1.092	1.012	1.178
pT	<0.001	1.253	1.188	1.323		<0.001	1.247	1.182	1.316
pN	<0.001	1.733	1.490	2.015		<0.001	1.688	1.450	1.964
pM	<0.001	2.444	2.114	2.824		<0.001	2.422	2.096	2.798
Examined lymph nodes	<0.001	0.691	0.597	0.799		0.035	0.778	0.617	0.982
Tumor size	0.134	1.132	0.962	1.332
Surg prim site	0.013	1.681	1.118	2.527
Second time characteristics
Marital	0.046	1.055	1.001	1.111
Site	0.043	0.926	0.860	0.998
Grade	0.091	1.204	0.971	1.493
pT	<0.001	1.312	1.197	1.438		<0.001	1.349	1.236	1.473
pN	0.07	1.159	0.988	1.359		0.034	1.190	1.013	1.397
pM	0.003	1.253	1.079	1.457		0.003	1.255	1.081	1.458
Examined lymph nodes						0.312	0.887	0.704	1.119
Chemotherapy	<0.001	0.715	0.642	0.795		<0.001	0.721	0.649	0.802

LASSO, least absolute shrinkage and selection operator; SCC, synchronous colorectal carcinomas; OS, overall survival.