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. 2022 Aug;11(8):1083–1095. doi: 10.21037/tau-22-113

Figure 5.

Figure 5

Propranolol affected the MAPK pathway and apoptosis signaling in vivo. (A) HE staining of control group and propranolol treatment group (hematoxylin-eosin, original magnification ×40). (B-F) Immunohistochemical detection of Ki-67, NHE1, P-MEK1/2, p-ERK1/2, caspase3 protein expression level in tumor tissue (original magnification ×40). (G-H) Western blot detection of, NHE1, p-MEK1/2, p-ERK1/2, cleaved-caspase3, Bax and Bcl-2 protein expression levels and statistics in tumor tissues. ns, no significance, *, P<0.05, **, P<0.01. Western blot was repeated three times. MAPK, mitogen-activated protein kinase; NHE1, Na+/H+ exchanger.