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. 2022 Aug;11(8):2688–2699. doi: 10.21037/tcr-21-2157

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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ACSL4 was significantly down-regulated in ccRCC tissues compared with normal kidney tissues. (A) ACSL4 mRNA expression was analyzed by qPCR in 16 pairs of ccRCC tissues and matched adjacent normal kidney tissues. (B) ACSL4 immunohistochemistry showed medium staining in normal kidney tissue; (C) low staining in ccRCC tissue; (D) not detected staining in ccRCC tissue. The top is magnified ×50, the below is magnified ×200. ***, P<0.001. ccRCC, clear cell renal cell carcinoma.