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. 2022 Aug;11(8):2688–2699. doi: 10.21037/tcr-21-2157

Figure 5.

Figure 5

Overexpression of ACSL4 promotes ferroptosis. (A) Western blot analysis of protein expression of ACSL4 in indicated cells. (B) ACSL4 cDNA elevated mRNA expression (*, P<0.05). (C,D) Overexpression of ACSL4 promoted erastin-induced cell death in 786-O and 769-P cells (n=3, **P<0.01, ***, P<0.001 vs. control cDNA group). (E,F) Lipid ROS and Fe2+ were assayed in 786-O and 769-P cells following treatment with erastin for 24 h (n=3, **, P<0.01 vs. control cDNA group). ccRCC, clear cell renal cell carcinoma; ROS, Reactive oxygen species.