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Knockdown of ACSL4 inhibits ferroptosis. (A) ACSL4 shRNA decreased mRNA expression (*, P<0.05). (B,C) Knockdown of ACSL4 inhibited erastin-induced cell death in A498 and RCC4 cells (n=3, **, P<0.01 vs. control shRNA group). (D,E) Lipid ROS and Fe2+ were assayed in A498 and RCC4 cells following treatment with erastin for 24 h (n=3, **, P<0.01 vs. control shRNA group).
