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. 2022 Aug;11(8):2688–2699. doi: 10.21037/tcr-21-2157

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2022 Translational Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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GO and pathway enrichment analysis of the ACSL4 co-expressed genes in TCGA-KIRC. (A) The most important pathway for gene enrichment of ACSL4 co-expression was Ubiquitin mediated proteolysis pathway (P=1.6E-3). (B,C) In the biological process and molecular function ontology, protein ubiquitination (GO: 0016567; P=5.0E-4) and ubiquitin-protein transferase activity (GO: 0004842; P=1.6E-15) constituted the majority of enriched GO categories. (D) In the CC ontology, endocytic vesicle (GO: 0030139; P=6.3E-10) ranked the top in the pathophysiological process. GO, Gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; BP, biological process; MF, molecular function; CC, cellular component; TCGA, The Cancer Genome Atlas; KIRC, kidney renal clear cell carcinoma.