Table 3. Prognostic value of an SS, SS-p16, SS-p21 and SS-p16-p21, as calculated with Cox PH model analysis.
| Characteristics | HR | 95% CI | P value |
|---|---|---|---|
| Simple Cox PH model analysis | |||
| SS | 2.17 | 1.24–3.80 | 0.007* |
| SS-p16 | 2.23 | 1.05–4.73 | 0.037* |
| SS-p21 | 1.43 | 0.50–4.07 | 0.51 |
| SS-p16-p21 | 2.74 | 1.29–5.81 | 0.009* |
| Multiple Cox PH model analysis correcting for age, pTNM stage I–III and adjuvant therapy | |||
| SS | 2.03 | 1.15–3.57 | 0.014* |
| SS-p16 | 2.10 | 0.97–4.53 | 0.059 |
| SS-p21 | 1.31 | 0.46–3.79 | 0.61 |
| SS-p16-p21 | 2.55 | 1.19–5.45 | 0.016* |
*, HR is significant. Cox PH; Cox proportional hazards; HR, hazard ratio; CI, confidence interval; SS, senescence signature; pTNM, pathological tumor-node-metastasis.