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. 2022 Aug;11(8):1567–1577. doi: 10.21037/tlcr-21-1004

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2022 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Schematic of study design. On the day prior to surgery, patients were infused with OTL38, a folate receptor-targeted near-infrared contrast agent that has been used in previous trials of intraoperative molecular imaging during video-assisted thoracic surgery (VATS-IMI) given known overexpression of folate receptor alpha in pulmonary cancers. On the day of surgery, localization of the lesion was attempted sequentially using white-light thoracoscopy, then IMI during robotic-assisted thoracic surgery (RIMI), and then confirmed with VATS-IMI as a control group. Fluorescence was evaluated on the back table following resection and then confirmed on a microscopic level postoperatively. RATS, robotic-assisted thoracic surgery.