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. 2022 Aug;11(8):1567–1577. doi: 10.21037/tlcr-21-1004

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2022 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Comparison of IMI during robotic-assisted thoracic surgery (RIMI) to intraoperative molecular imaging during video-assisted thoracic surgery (VATS-IMI). Panel A depicts representative images comparing VATS-IMI and RIMI in the same patient. Panel B shows mean fluorescence intensity (MFI) of lesion and background measurements, stratified by imaging modality (RIMI vs. VATS-IMI). Each line links lesion and background measurements from the same subject. Panel C depicts tumor-to-background ratio (TBR) of lesions compared to normal lung parenchyma as background, when stratified by imaging modality. Each point on the plot represents a TBR for an individual patient. Mean TBR was >2 for both RIMI and VATS-IMI, and there were no significant differences between groups. A.U., arbitrary unit; IMI, intraoperative molecular imaging.