Fig. 3.

Immune and fibrotic responses in female Cyp2c70 KO mice are alleviated with SC-435 treatment. A: Morphological response to SC-435 treatment in WT and Cyp2c70 KO mice. From top to bottom panel: Hematoxylin and eosin (H&E), Cytokeratin-19 (Ck-19), F4/80, and Sirius Red–stained liver sections (original magnification 10X) from the indicated genotypes and treatments groups. Scale bar, 250 μm. Quantification of positive B: Ck-19, C: F4/80 cells per mm², and D: Percent Sirius Red positive area of the entire liver section. Asterisks indicate significant differences between groups. Median values (line), interquartile range (boxes), and min to max values are shown (whiskers) (∗P < 0.05, ∗∗P < 0.01, ∗∗∗∗P < 0.0001); n = 5–9 mice per group.