Fig. 5.

Female mouse liver RNA-Seq analysis. Venn diagram showing the number of differentially expressed genes identified in Cyp2c70 KO mice versus WT and Cyp2c70 KO mice–fed chow versus chow plus SC-435. Intersection represents the subset of genes (488 downregulated plus 85 upregulated) whose expression is normalized toward WT levels. Change in expression is displayed as change in Z-score on heatmap for representative genes from the indicated pathways that were normalized with SC-435 treatment. Each column in the heatmap represents an individual animal.