Table 3.
Japanese Knee Osteoarthritis Measure (JKOM) and Japanese Orthopaedic Association (JOA) scores at W0, W4, and W12.
| W0 | W4 | W12 | p-Value LMM | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Values | Values | Difference (95% CI) |
p-Value 1 | Values | Difference (95% CI) |
p-Value 1 | ||||||
| 6AA | Placebo | 6AA | Placebo | 6AA | Placebo | |||||||
| JKOM | I | 45.0 | 37.7 | 36.9 | 35.4 | −5.8 | 0.0199 * | 23.1 | 31.8 | −15.9 | 0.0004 * | <0.0001 * |
| (18.4) | (16.3) | (19.2) | (15.0) | (−10.6 to −1.0) | (19.1) | (14.4) | (−24.4 to −7.5) | |||||
| II | 7.9 | 7.9 | 6.1 | 7.3 | −1.2 | 0.0124 * | 4.6 | 6.6 | −2.0 | 0.0094 * | 0.0026 * | |
| (3.1) | (2.4) | (3.6) | (2.5) | (−2.1 to −0.3) | (3.3) | (2.2) | (−3.6 to −0.5) | |||||
| III | 4.9 | 5.1 | 3.0 | 5.0 | −1.9 | 0.0002 * | 2.6 | 4.6 | −1.8 | 0.0001 * | 0.0010 * | |
| (4.0) | (3.3) | (4.0) | (3.3) | (−2.8 to −0.9) | (3.6) | (3.2) | (−2.6 to −1.0) | |||||
| IV | 3.3 | 4.0 | 2.7 | 3.8 | −0.3 | 0.4826 | 2.6 | 3.4 | 0 | 0.9357 | 0.9533 | |
| (2.3) | (2.6) | (2.0) | (2.2) | (−1.2 to 0.6) | (2.0) | (2.3) | (−1.0 to 1.0) | |||||
| V | 1.8 | 1.9 | 1.6 | 1.8 | −0.1 | 0.3534 | 1.1 | 1.7 | −0.5 | 0.0222 * | 0.0052 * | |
| (0.9) | (0.9) | (0.9) | (0.9) | (−0.4 to 0.1) | (1.0) | (0.7) | (−1.0 to −0.1) | |||||
| Total | 17.9 | 18.9 | 13.4 | 17.9 | −3.5 | 0.0014 * | 10.9 | 16.3 | −4.4 | 0.0016 * | 0.0010 * | |
| (II–V) | (8.9) | (7.4) | (8.9) | (7.4) | (−5.6 to −1.4) | (8.4) | (7.0) | (−7.0 to −1.8) | ||||
| JOA | Mean | 91.0 | 91.2 | 91.8 | 91.8 | 0.2 | 0.7305 | 93.6 | 92.1 | 1.7 | 0.0901 | 0.0210 * |
| (3.0) | (2.5) | (3.4) | (2.6) | (−1 to 1.4) | (4.0) | (3.2) | (−0.3 to 3.7) | |||||
Data are represented as mean (SD); CI, confidence interval; 1 Student’s t-test assessed the differences between the 6AA and placebo groups of change from W0 at W4 and W12 weeks; LMM, linear mixed model; * p < 0.05 between the 6AA and placebo groups.