Table 4.
The serum CTX-II, C2C, uric acid, and plasma TNF-α levels at W0, W4, and W12.
| W0 | W4 | W12 |
p-Value LMM |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Values | Values | Difference (95% CI) |
p-Value 1 | Values | Difference (95% CI) |
p-Value 1 | |||||
| 6AA | Placebo | 6AA | Placebo | 6AA | Placebo | ||||||
| CTX-II | 465.0 | 487.6 | 465.0 | 501.3 | −13.7 | 0.4462 | 485.7 | 479.0 | 29.3 | 0.1817 | 0.0680 |
| (pg/mL) | (167.2) | (192.2) | (165.5) | (181.4) | (−49.6 to 22.2) | (159.9) | (165.8) | (−14.2 to 72.7) | |||
| C2C | 330.4 | 339.2 | 346.4 | 358.2 | −3.1 | 0.7825 | 364.5 | 354.2 | 19.1 | 0.2726 | 0.1551 |
| (ng/mL) | (51.3) | (40.3) | (38.7) | (39.1) | (−25.7 to 19.5) | (70.5) | (43.3) | (−15.5 to 53.8) | |||
| Uric acid | 4.6 | 4.9 | 4.3 | 5.6 | −0.9 | 0.0002 * | 4.4 | 5.4 | −0.5 | 0.0383 * | 0.0407 * |
| (mg/dL) | (1.2) | (1.2) | (1.1) | (1.1) | (−1.3 to −0.4) | (1.1) | (1.2) | (−0.9 to 0) | |||
| TNF-α | 4.9 | 5.1 | 5.1 | 5.4 | −0.1 | 0.6805 | 4.7 | 5.1 | −0.2 | 0.6353 | 0.6288 |
| (pg/mL) | (1.6) | (2.5) | (1.8) | (2.7) | (−0.8 to 0.6) | (2.1) | (3.2) | (−1.0 to 0.6) | |||
Data are represented as mean (SD); CI, confidence interval; LMM, linear mixed model; 1 Student’s t-test assessed the differences between the 6AA and placebo groups of change from W0 at W4 and W12 weeks. * p < 0.05 between the 6AA and placebo groups.