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. 2022 Aug 29;14(17):3561. doi: 10.3390/nu14173561

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of aqueous extract on the pancreatic tissue. Pancreas of normal mice revealed intact boundary and normal morphology of B cells. The diabetic mice group revealed focal necrosis (arrow) in pancreatic tissue due to the effect of STZ. Mice treated with metformin showed restoration of intact structure of islets of Langerhans. Both 500 mg/kg and 800 mg/kg doses of extract restored the boundary of islets of Langerhans as well as the morphology and number of beta cells (*). fn = focal necrosis.