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(A) Crystal structure of K-Ras(G12R)·GDP·4 adduct. Fo–Fc omit map is depicted for compound 4 and arginine 12 in gray mesh (σ = 2.0). (B) Scheme depicting the reaction between compound 4 and the Arg12 residue. (C) Comparison of the structures of unliganded K-Ras(G12R)·GDP (PDB: 4QL3) and K-Ras(G12R)·GDP·4 adduct. (D) Comparison of the structures of K-Ras(G12C)·GDP·MRTX849 (PDB: 6UT0) and K-Ras(G12R)·GDP·4 adduct.
