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. 2022 Aug 23;13:954235. doi: 10.3389/fimmu.2022.954235

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Copyright © 2022 Xiao, Wang, Zou, Yang, Wang, Xin, Tu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HSCT in combination with CAR T cell therapy to enhance efficacy. (A) Standard-of-care CAR T cell therapy following consolidative allo-HSCT. (B) Concurrent infusion of allo-CAR T cells and allo-HSCT to enhance antitumor effects and prolong the persistence of allo-CAR T cells without additional gene editing against graft rejection. (C) Allo-HSCT following allo-CAR T cell therapy for MRD clearance. (D) High-dose chemotherapy conditioning and autologous stem cell transplantation to remodel the immune environment for subsequent CAR T cell therapy. allo-HSC, allogeneic haemopoietic stem cell.