Fig. 2.

The dynamics of the m6A methylome. The methylated adenosine group is colored yellow. m6A writers, erasers and readers are the protein factors involved in the cellular m6A methylation event. m6A writers catalyze the covalent conversion of Adenosine (A) to m6A on target RNAs. FTO and ALKBH5 are m6A erasers that reverse the methylation. A diverse set of m6A readers selectively bind m6A and mediate post-transcriptional processes on m6A-containing RNA including ① alternative splicing ② nuclear export and RNA localization ③ mRNA degradation ④ 7-Methylguanosine cap-dependent translation ⑤ 7-Methylguanosine cap-independent translation ⑥ and mRNA stabilization