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. 2022 Sep 8;13:465. doi: 10.1186/s13287-022-03157-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IDO-1 of hADSCs induced by pretreated IFN-γ combined with KYNA. (A) IFN-γ (20 ng/mL) combined with KYNA (50 μM) stimulated P5 hADSCs pattern. (B) Volcano plot of P5 I + K-hADSCs and hADSCs transcriptome sequencing. (C) Cluster analysis of hADSCs and IFN-γ and I + K-hADSCs. (D) KEGG enrichment analysis of hADSCs and I + K-hADSCs. (E) qPCR results of each group treated or untreated for 24 h, mRNA expression levels of IDO-1, iNOS and COX-2 in Control group (P5 hADSCs), IFN-γ group (IFN-γ 20 ng/ml treated P5 hADSCs), KYNA + IFN-γ group (IFN-γ 20 ng/ml, KYNA 50 μM treated P5 hADSCs). (F) Western blot detected the hADSCs and I + K-hADSCs protein expression levels of IDO-1, iNOS, and COX-2. Data are represented as mean ± SEM