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. 2022 Sep 8;13:465. doi: 10.1186/s13287-022-03157-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The IFN-γ- and KYNA-primed hADSCs can promoted the polarization of M2 macrophages. (A) Rat with the TNBS-induced colon fibrosis were killed on day 46 to harvest the spleen, mLN (n = 3). CD45RA⁺ B cells, CD3⁺ T cells, CD4⁺ T cells, CD8⁺ T cells, CD43⁺His48^Int−Lo monocytes and CD43⁺His48^Hi neutrophils in spleens of each group were detected by flow cytometry and statistical (Int-Lo means interval lower positive cells, Hi means strongly positive cells); (B) Blood routine analysis of WBC, lymphocyte, monocytes, and neutrophil in peripheral blood after primed hADSCs treatment (n = 3); (C) Analysis of macrophage subsets change. The infiltration of CD86⁺M1 macrophages and CD206⁺M2 macrophages in spleens of each group was detected; the following statistical figure shows the analysis of CD86⁺M1 and CD206⁺M2 macrophages in the CD68⁺ cell population (n = 3); data are represented as mean ± SEM