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. 2022 Sep 8;10:134. doi: 10.1186/s40478-022-01424-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Case selection according to Braak staging system. a Diagram indicating the amount of Lewy body pathology in the regions used in the study according to Braak staging criteria. Severity of pathology at early-mid stage Braak 3/4 and late Braak stage 6 is highlighted by colours shown in reference to the key. Table indicates how many cases used for each region and disease group. b Panel of representative pathology images from a Braak stage 3/4 brain, highlighting the level of alpha-synuclein pathology in each region at this stage of disease at 20 × and 40 × magnification. Regions are labelled as follows: SN Substantia nigra; Cau Caudate; Put Putamen; Temp Temporal cortex; Para Parahippocampal gyrus; Cing Cingulate cortex; Fron Frontal cortex; Pari Parietal cortex. Black arrows show Lewy body presence and red arrows Lewy neurites. All scale bars represent 10 μm