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. 2022 Sep 8;10:134. doi: 10.1186/s40478-022-01424-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Mitochondrial analysis of label free proteomic data. Oxidative phosphorylation pathway diagram with per region overlay of proteomic expression for the putamen and frontal cortex in early PD compared to controls, a and late PD compared to controls, e. Red represents upregulation and green represents downregulation. Intensity of colour indicates level of altered expression. b, f Complex proteins totalled and ratioed to citrate synthase across brain regions and disease stages. Two-way ANOVA with Sidek’s multiple comparison post-hoc testing was performed for each complex/citrate synthase and statistically significant results are demonstrated on graphs with * representing p < 0.03, ** representing p < 0.002, *** representing p < 0.0002 and **** representing p < 0.0001. Bars represent SEM. c, g Table indicating the % of significantly altered proteins per pathway for the sub-functions of the mitochondria as determined through Mitominer and Panther. Regions are colour-coded for severity of pathology present at that stage of disease as shown in key. d HADHB and ACAT1 expression across multiple brain regions, Graphs and statistics were completed using GraphPad Prism v8

Fig. 6 — Mitochondrial analysis of label free proteomic data. Oxidative phosphorylation pathway diagram with per region overlay of proteomic expression for the putamen and frontal cortex in early PD compared to controls, a and late PD compared to controls, e. Red represents upregulation and green represents downregulation. Intensity of colour indicates level of altered expression. b, f Complex proteins totalled and ratioed to citrate synthase across brain regions and disease stages. Two-way ANOVA with Sidek’s multiple comparison post-hoc testing was performed for each complex/citrate synthase and statistically significant results are demonstrated on graphs with * representing p < 0.03, ** representing p < 0.002, *** representing p < 0.0002 and **** representing p < 0.0001. Bars represent SEM. c, g Table indicating the % of significantly altered proteins per pathway for the sub-functions of the mitochondria as determined through Mitominer and Panther. Regions are colour-coded for severity of pathology present at that stage of disease as shown in key. d HADHB and ACAT1 expression across multiple brain regions, Graphs and statistics were completed using GraphPad Prism v8