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. 2022 Sep 8;10:134. doi: 10.1186/s40478-022-01424-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Early stage PD overlap against Late stage PD. Pie charts show the number of GO terms (Biological processes, molecular functions or cellular components) that are overlapping between early PD (Braak stage 3/4) and late stage PD (Braak stage 6) in either the putamen, a region moderately affected at Braak stage 3/4 but severely affected at Braak stage 6, and the frontal cortex, a region not affected at Braak stage 3/4 but mildly affected at Braak stage 6. Colour coded for severity of pathology present at that stage of disease as shown in key