Table 4.
Mitochondrial proteins that show altered expression
| ID | Name | SN | Put | Para | Fron |
|---|---|---|---|---|---|
| ACO1 | Aconitase 1 | 1.017 | 1.105 | 1.725 | 1.036 |
| ACO2 | Aconitase 2 | 1.218 | − 1.131 | 1.186 | 1.252 |
| AIFM1 | Apoptosis inducing factor mitochondria associated 1 | 1.219 | 1.273 | − 1.072 | 1.246 |
| ATP5F1A | ATP synthase F1 subunit alpha | 1.748 | − 1.437 | 1.243 | 1.217 |
| ATP5F1B | ATP synthase F1 subunit beta | 2.617 | 1.057 | 1.091 | 1.37 |
| ATP5F1C | ATP synthase F1 subunit gamma | 3.771 | − 1.132 | − 1.386 | 1.383 |
| ATP5F1D | ATP synthase F1 subunit delta | − 1.096 | 1.168 | − 1.281 | 1.208 |
| ATP5ME | ATP synthase membrane subunit e | 1.53 | − 1.019 | 1.18 | − 1.395 |
| ATP5MF | ATP synthase membrane subunit f | − 1.163 | − 1.207 | 1.19 | 1.089 |
| ATP5MG | ATP synthase membrane subunit g | 1.452 | 1.015 | 1.068 | 1.145 |
| ATP5PB | ATP synthase peripheral stalk-membrane subunit b | 2.056 | − 1.114 | 1.256 | 1.041 |
| ATP5PD | ATP synthase peripheral stalk subunit d | − 1.051 | − 1.153 | 1.328 | 1.137 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | − 1.599 | 1.073 | 1.265 | 1.11 |
| ATP5PO | ATP synthase peripheral stalk subunit OSCP | 2.228 | − 1.136 | 1.251 | 1.247 |
| ATPAF2 | ATP synthase mitochondrial F1 complex assembly factor 2 | − 2.474 | 1.373 | 1.024 | 1.221 |
| CAT | Catalase | 1.599 | − 1.591 | 1.273 | − 1.07 |
| COX4I1 | Cytochrome c oxidase subunit 4I1 | 1.209 | − 1.057 | 1.389 | 1.403 |
| COX5A | Cytochrome c oxidase subunit 5A | − 1.4 | − 1.124 | 1.32 | 1.476 |
| COX5B | Cytochrome c oxidase subunit 5B | 1.15 | − 1.009 | 1.169 | 1.255 |
| COX6A1 | Cytochrome c oxidase subunit 6A1 | 1.39 | − 1.198 | − 1.158 | 1.306 |
| COX6B1 | Cytochrome c oxidase subunit 6B1 | − 1.107 | 1.311 | − 1.683 | 2.323 |
| COX7A2 | Cytochrome c oxidase subunit 7A2 | 1.037 | − 1.333 | − 1.694 | 1.367 |
| COX7C | Cytochrome c oxidase subunit 7C | − 1.601 | − 1.15 | − 1.115 | 1.193 |
| CYB5R3 | Cytochrome b5 reductase 3 | 1.053 | − 1.134 | − 1.002 | 1.042 |
| CYC1 | Cytochrome c1 | 1.512 | − 1.055 | 1.381 | 1.375 |
| CYCS | Cytochrome c, somatic | 1.358 | 1.085 | 1.091 | 1.62 |
| FIS1 | Fission, mitochondrial 1 | − 1.254 | − 1.043 | 1.106 | − 1.093 |
| GPD2 | Glycerol-3-phosphate dehydrogenase 2 | 1.69 | 1.06 | 1.166 | 1.016 |
| GPX4 | Glutathione peroxidase 4 | 1.505 | − 1.039 | 1.035 | − 1.114 |
| GSR | Glutathione-disulfide reductase | − 1.592 | − 1.247 | 1.276 | 1.781 |
| HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10 | − 1.79 | − 1.16 | 1.149 | − 1.032 |
| HTRA2 | HtrA serine peptidase 2 | 1.414 | 1.032 | 1.047 | 1.123 |
| MAOA | Monoamine oxidase A | 1.055 | − 1.118 | 1.102 | 1.213 |
| MAOB | Monoamine oxidase B | 1.543 | − 1.111 | − 1.253 | − 1.089 |
| MAP2K4 | Mitogen-activated protein kinase inase 4 | 1.469 | 1.163 | 1.155 | − 1.012 |
| MAPK9 | Mitogen-activated protein kinase 9 | − 9.433 | NA | 1.238 | − 1.14 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 2.2 | − 2.204 | − 16.992 | 1.588 |
| MT-CO1 | Cytochrome c oxidase subunit I | 1.233 | − 1.936 | NA | NA |
| MT-CO2 | Cytochrome c oxidase subunit II | 2.063 | − 1.129 | 1.227 | 1.577 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | 5.659 | − 1.082 | 1.048 | 1.167 |
| NDUFA10 | NADH:ubiquinone oxidoreductase subunit A10 | 1.391 | − 1.067 | 1.046 | 1.499 |
| NDUFA11 | NADH:ubiquinone oxidoreductase subunit A11 | 1.174 | − 1.357 | 1.579 | 1.293 |
| NDUFA12 | NADH:ubiquinone oxidoreductase subunit A12 | 1.45 | − 1.196 | 1.234 | 1.194 |
| NDUFA13 | NADH:ubiquinone oxidoreductase subunit A13 | − 1.378 | 1.085 | 1.526 | 2.629 |
| NDUFA2 | NADH:ubiquinone oxidoreductase subunit A2 | 1.301 | − 1.154 | 1.166 | − 1.121 |
| NDUFA3 | NADH:ubiquinone oxidoreductase subunit A3 | 4.303 | 1.12 | − 2.074 | − 1.255 |
| NDUFA4 | NDUFA4 mitochondrial complex associated | 1.808 | − 1.156 | 1.54 | 1.187 |
| NDUFA5 | NADH:ubiquinone oxidoreductase subunit A5 | 1.133 | − 1.19 | 1.183 | 1.425 |
| NDUFA6 | NADH:ubiquinone oxidoreductase subunit A6 | 1.479 | − 1.104 | 1.212 | 2.249 |
| NDUFA7 | NADH:ubiquinone oxidoreductase subunit A7 | 1.192 | 1.044 | 1.254 | − 1.507 |
| NDUFA8 | NADH:ubiquinone oxidoreductase subunit A8 | 1.047 | − 1.109 | − 1.994 | 1.062 |
| NDUFA9 | NADH:ubiquinone oxidoreductase subunit A9 | 1.442 | − 1.069 | 1.245 | 1.297 |
| NDUFB10 | NADH:ubiquinone oxidoreductase subunit B10 | 1.506 | 1.038 | 1.131 | 1.198 |
| NDUFB11 | NADH:ubiquinone oxidoreductase subunit B11 | − 1.076 | − 1.018 | 1.005 | 1.448 |
| NDUFB3 | NADH:ubiquinone oxidoreductase subunit B3 | 1.592 | 1.025 | 1.074 | 1.228 |
| NDUFB4 | NADH:ubiquinone oxidoreductase subunit B4 | − 1.122 | − 1.039 | 1.156 | 1.261 |
| NDUFB6 | NADH:ubiquinone oxidoreductase subunit B6 | 3.766 | 1.078 | − 5.285 | − 1.123 |
| NDUFB7 | NADH:ubiquinone oxidoreductase subunit B7 | 1.091 | 2.52 | NA | NA |
| NDUFB9 | NADH:ubiquinone oxidoreductase subunit B9 | − 1.002 | 1.031 | 1.203 | 1.278 |
| NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1 | 1.415 | − 1.151 | 1 | 1.147 |
| NDUFS2 | NADH:ubiquinone oxidoreductase core subunit S2 | 5.867 | − 1.019 | -1.016 | 1.061 |
| NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3 | 1.224 | 1.038 | 1.163 | 1.445 |
| NDUFS4 | NADH:ubiquinone oxidoreductase subunit S4 | 1.384 | 1.062 | 1.099 | − 2.262 |
| NDUFS5 | NADH:ubiquinone oxidoreductase subunit S5 | 1.534 | − 1.249 | − 1.324 | 1.281 |
| NDUFS6 | NADH:ubiquinone oxidoreductase subunit S6 | − 1.329 | − 1.261 | − 1.138 | 1.254 |
| NDUFS7 | NADH:ubiquinone oxidoreductase core subunit S7 | 1.621 | − 1.274 | 1.071 | 1.48 |
| NDUFS8 | NADH:ubiquinone oxidoreductase core subunit S8 | 1.521 | − 1.017 | 1.046 | 1.271 |
| NDUFV1 | NADH:ubiquinone oxidoreductase core subunit V1 | 1.301 | − 1.153 | 1.011 | 1.521 |
| NDUFV2 | NADH:ubiquinone oxidoreductase core subunit V2 | − 1.217 | − 1.056 | 1.593 | 1.554 |
| OGDH | Oxoglutarate dehydrogenase | − 1.284 | 1.071 | − 1.097 | 1.123 |
| PARK7 | Parkinsonism associated deglycase | 1.405 | − 1.064 | − 1.18 | − 1.059 |
| PDHA1 | Pyruvate dehydrogenase E1 alpha 1 subunit | − 1.167 | − 1.565 | 1.106 | 1.253 |
| PRDX3 | Peroxiredoxin 3 | 1.393 | 1.08 | 1.154 | 1.267 |
| PRDX5 | Peroxiredoxin 5 | − 1.19 | − 1.184 | − 1.11 | 1.079 |
| RHOT2 | Ras homolog family member T2 | − 1.367 | NA | NA | NA |
| SDHA | Succinate dehydrogenase complex flavoprotein subunit A | 1.492 | 1.009 | 1.202 | − 1.412 |
| SDHB | Succinate dehydrogenase complex iron sulfur subunit B | 1.519 | − 1.121 | − 1.056 | 1.116 |
| SNCA | Synuclein alpha | 2.154 | − 1.311 | 1.229 | 1.091 |
| SOD2 | Superoxide dismutase 2 | 1.485 | − 1.35 | − 1.073 | 1.215 |
| TXN2 | Thioredoxin 2 | − 1.908 | NA | NA | NA |
| UQCRB | Ubiquinol-cytochrome c reductase binding protein | − 1.15 | − 1.03 | 1.17 | − 1.267 |
| UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1 | 2.346 | − 1.294 | − 1.469 | 1.473 |
| UQCRC2 | Ubiquinol-cytochrome c reductase core protein 2 | 1.29 | − 1.138 | − 1.297 | 1.141 |
| UQCRFS1 | Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | − 1.21 | − 1.002 | − 1.01 | 1.191 |
| UQCRH | Ubiquinol-cytochrome c reductase hinge protein | − 1.691 | NA | − 3.694 | NA |
| UQCRQ | Ubiquinol-cytochrome c reductase complex III subunit VII | 2.212 | 1.027 | 1.057 | 1.069 |
| VDAC1 | Voltage dependent anion channel 1 | 2.691 | − 1.067 | 1.352 | 1.057 |
| VDAC2 | Voltage dependent anion channel 2 | 1.57 | − 1.004 | 1.053 | 1.209 |
| VDAC3 | Voltage dependent anion channel 3 | 1.723 | − 1.207 | 1.055 | 1.208 |
All proteins involved in mitochondrial dysfunction pathway (as determined by IPA) and the fold change expression for each in early PD compared to controls per region