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. 2022 Sep 9;20:283. doi: 10.1186/s12916-022-02489-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Profiling T cells in BRCA1 carriers. A t-SNE plot displaying the CD3⁺CD8⁺ T cells in BRCA1 and non-BRCA1 carriers. B t-SNE plot showing the distribution of clonal TCRs and pie chart showing the percentage of clonal TCRs in BRCA1 and non-BRCA1 carriers. C Violin plot showing the PD1 expression level in clonal and non-clonal CD8+ T cells. D Violin plot showing the PD1 expression level in BRCA1 mutation carriers and normal controls for clonal CD8+ T cells. Statistical significance was estimated using a two-sided Wilcoxon rank-sum test