Table 3. Outcome by prior smallpox vaccination status among monkeypox cases, 36 WHO European Region countries, 7 March–23 August 2022 (n = 3,502 cases).

Variables		Vaccinated		Unvaccinated		Crude OR	95% CI	Adjusted OR	95% CI
		n	%	n	%
Total cases		528	15.1	2,974	84.9
Age group (years)	18–30	49	5.7	817	94.3	Ref	Ref	Ref	Ref
	0–17	0	0	10	100	0.79	0.01–6.26	7.95	1.46–30.44
	31–40	94	6.8	1,298	93.2	1.20	0.85–1.73	0.97	0.61–1.57
	41–50	130	16.0	680	84.0	3.17	2.26–4.50	0.87	0.50–1.51
	51–60	189	58.9	132	41.1	23.62	16.56–34.24	0.3	0.08–0.86
	> 60	62	69.7	27	30.4	37.53	22.30–64.83	0.77	0.15–2.61
	Unknown	4	28.6	10	71.4	Not calculated		Not calculated
Gendera	Male	516	15.0	2,927	85.0	Ref	Ref	Not calculated
	Female	11	19.6	45	80.4	1.43	0.71–2.66
	Other	1	33.3	2	66.7	3.40	0.31–25.62
Hospitalisationb	Not hospitalised	495	15.2	2,758	84.8	Ref	Ref	Ref	Ref
	Hospitalised	12	11.3	94	88.7	0.74	0.39–1.29	1.07	0.53–1.97
	Unknown	21	14.7	122	85.3	Not calculated		Not calculated
Health worker	No	253	15.0	1,437	85.0	Ref	Ref	Not calculated
	Yes	2	4.9	39	95.1	0.36	0.07–1.07
	Unknown	273	15.4	1,498	84.6	Not calculated

CI: confidence interval; OR: odds ratio; Ref: reference.

^a Gender collected in TESSy as female, male, other (e.g. transgender) or unknown (not shown in table).

^b Hospitalisation is defined as hospitalisation for clinical care (n = 197). Hospitalisation for known isolation (n = 129) is included as not hospitalised for clinical care. Regressions were performed for cases for which there was complete data for the specific variables included in each model. Adjusted OR includes hospitalisation as a binary outcome and age (categorical) and vaccination (binary) as explanatory variables. Vaccinated include those vaccinated for smallpox prior to this outbreak.