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PLAD, PLD and F-Dox biodistribution in WEHI-164 tumor bearing mice at 72 h (PLAD, PLD) and 2 h (F-Dox) post-dose. Data are mean with SEM; n=7 for PLD and PLAD, n=5 for F-Dox. ANOVA with Tukey's test (A, B, D) or unpaired t-test (C); *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ns: not significant. F-Dox: free doxorubicin, PLD: pegylated liposomal doxorubicin, PLAD: pegylated liposomal alendronate-doxorubicin.
