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. 2022 Sep 1;6(4):451–464. doi: 10.7150/ntno.75045

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Doxorubicin accumulation in the tumor by fluorescence microscopy. (A) Doxorubicin fluorescence in tumor sections showed higher uptake in tumors from PLAD group. Each point is one slide image, 4-11 images/tumor, 23 total animals (PLAD n=7, PLD n=8, F-Dox n=5, and vehicle n=3), bars represent group mean; ANOVA and Dunnett's test; *p<0.05, **p<0.01. (B) Representative images shown. F-Dox: free doxorubicin, PLD: pegylated liposomal doxorubicin, PLAD: pegylated liposomal alendronate doxorubicin; DAPI is a nuclear dye.