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. 2022 Sep 1;6(4):451–464. doi: 10.7150/ntno.75045

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PLAD and PLD showed superior antitumor efficacy over free doxorubicin in the WEHI-164 fibrosarcoma model. (A) Tumor growth curves showing group mean with SEM; ANOVA with Dunnett's test; *versus F-Dox, p = 0.0267 and 0.0455, respectively, for PLAD and PLD. (B) Kaplan-meier curves for survival endpoint of 5-fold tumor growth; Log-rank tests. PLD, PLAD, and F-Dox, n=9 each group; vehicle n=6. F-Dox: free doxorubicin, PLD: pegylated liposomal doxorubicin, PLAD: pegylated liposomal alendronate doxorubicin.