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. 2022 Aug 29;18(14):5391–5404. doi: 10.7150/ijbs.73673

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MBP levels in different groups showing the preservative benefit of VitD on myelin protein. (A) MBP levels at the epicenter, rostral and caudal sections were analyzed. Western blotting showed significant decreases in MBP levels after contusion and transection injury in the epicenters, and VitD treatment ameliorated such damage except for the deficient animals with transection injuries. Rostral rather than caudal spinal cords also suffered from obvious myelin damages in both cohorts. (B) Immunofluorescence staining in the epicenter of mouse spinal cords with transection injury showed increased myelination (indicated by MBP, green) surrounding the axons (indicated by NF200, red). Original magnification 200X (left) and 400X (right). (F) Western blotting of MBP protein expression in the epicenter also showed an obvious increase in MBP after VitD treatment. Data are presented as mean ± SD, and n=3.^*p < .05, ^**p < .01, ^***p < .001.