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. 2022 Aug 29;18(14):5391–5404. doi: 10.7150/ijbs.73673

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TEM demonstrated that VitD treatment preserved myelin sheath integrity. Myelin integrity in the epicenters and rostral segments were evaluated by myelin thickness measurement and g-ratio analysis. (A) VitD deficiency did not cause myelin damage in SHAM animals. (B and C) Both contusion and transection injury caused significant myelin breaks in the epicenters. In line with the functional and MBP analysis, VitD increased the integrity of myelin in all pairs except for the transection rats with prior VitD-deficiency. (D and E) Rostral tissues showed similar trend that demyelination could be clearly witnessed in both models, and VitD also showed its therapeutic values in all contusion groups. Again, it became less effective in rats with transection injury. Data are shown as mean ± SD, and n=3. Scale bars are 4µm, 1µm and 200nm in 1.65K, 5.2K and 28.5K magnified images, respectively. ^*p < .05, ^**p < .01, ^***p < .001.