Table 2.
Autophagy-related proteins involved in genome stability through non-autophagic pathway
| Autophagy-related proteins | Target molecule | Functions | References |
|---|---|---|---|
| mTORC1 | S6K/FANCD2, 4E-BP1 | promotes DNA repair and replication fork survival | 81,82 |
| 4E-BP /S6K1/cyclin D and cyclin E | regulates G1 phase progression | 107 | |
| S6K1 | stabilizes the genome in G2/M phase | 109 | |
| ATG5 | Mis18α | microsatellite instability and DNA mismatch repair deficiency | 93 |
| p62 | DLK1/NADPH oxidase/ROS | induces genomic instability | 95 |
| ULK1 | PARP-1 | is as a DNA damage factor | 96 |
| Beclin1 | DNA topoisomerase IIβ/53bP1 | is involved in DNA repair | 97 |
| Zwint-1 | Protects chromosomestability | 98 | |
| ATG7 | p53 | Regulates cell cycle during metabolic stress; | 73 |
| ETS2/miRNA196b/FOXO1/p27 Axis | Knockdown of ATG7 induces cell cycle arrest in G2/M phase. | 74 | |
| parkin | Cdc20/Cdh1/APC/C | Protects chromosomestability | 99 |
| Myt1/CDC2 | Induces cell cycle arrest in G2/M phase; | 101 | |
| cyclin D1 and cyclin E1 | Knockdown or inactivation of PARK2 accelerates cell cycle progression; | 102 | |
| VEGFR2/Akt/cyclin D1 | Promoted G1 phase cell-cycle arrest and mitigated the proliferation. | 106 | |
| FIP200 | p21/cyclin D1 | Inhibits G1-S phase progression and cell proliferation | 112 |
| SpATG10 | Is essential for normal cell cycle progression in S. pombe. | 113 |