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. 2022 Aug 29;18(14):5475–5488. doi: 10.7150/ijbs.73790

Figure 4.

Figure 4

The relationship between ferroptosis regulators and DUBs. Schematic overview of DUBs involved in the process of ferroptosis by regulating multiple signal pathways, including system xc--GSH-GPX4 pathway, lipid metabolism pathways and iron metabolism pathway. Moreover, PdPT, a pan-DUB inhibitor, could decrease GPX4 expression through inhibiting various DUBs.