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. 2022 Aug 29;18(14):5459–5474. doi: 10.7150/ijbs.74546

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NCT-502 inhibits BCa progression by targeting PHGDH. (A) The IC50 value of NCT-502 in T24 cell line (B) Schematic diagram of NCT-502 xenograft model experiment (C-D) The subcutaneous xenograft mouse model showed that NCT-502 affects BCa growth in vivo (n=3, P-value <0.05) (E-F) Representative IHC images of PHGDH and SLC7A11 in mouse subcutaneous tumor tissues. Scale bars: 50/25 μm. (G-H) Colony formation and CCK-8 assays were used to assess cell viability after NCT-502 treatment in the T24 cell line. (I) Culture process of BCa organoids. (J-K) Effect of NCT-502 on organoid cell viability. (L) Electron microscopy technique was implemented for determining the changes in cellular mitochondria to assess ferroptosis. *p<0.05, **p<0.01, ***p<0.001.